| Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. | |
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MedLine Citation:
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PMID: 21400246 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Keloid, a fibro-proliferative benign tumor of skin, is characterized by an enriched milieu of growth factors and an abundant accumulation of extracellular matrix (ECM). Transforming growth factor (TGF)-β1 is well known as the crucial fibrogenic cytokine promoting ECM production and tissue fibrosis in keloid forming. Epigenetic modifications have been shown to play a role in the pathogenesis of cancer as well as autoimmune and inflammatory disorders. Recent publication reports epigenetic modifications in keloid fibroblasts that include an altered pattern of DNA methylation and histone acetylation. Therefore, the field of epigenetics may provide a new therapeutic idea for keloid treatment strategies. Currently, there is some evidence from experimental studies that histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) causes abrogation of TGF-β1 induced collagen synthesis in skin fibroblasts. Furthermore, TSA could suppress proliferation and induce apoptosis in a broad spectrum of tumor cells both in vitro and in vivo. These findings suggest that TSA could also cause abrogation of TGF-β1 induced collagen synthesis and induce apoptosis of proliferating keloid fibroblasts. |
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Authors:
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Jian-Sheng Diao; Wen-Sen Xia; Cheng-Gang Yi; Ying-Mei Wang; Bing Li; Wei Xia; Bei Liu; Shu-Zhong Guo; Xu-De Sun |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Archives of dermatological research Volume: - ISSN: 1432-069X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Plastic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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