| Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells. | |
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MedLine Citation:
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PMID: 20573419 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Plasmacytoid dendritic cells (PDC) represent the main type I interferon (IFN-I) producing cells. Emerging evidence supports a role for IFN-I in autoimmune diseases. Given the central role of PDC in the pathogenesis of systemic lupus erythematosus (SLE), we investigated the effect of Trichostatin A (TSA), a prototypic histone deacetylase inhibitor, on PDC activation. TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory cytokines TNFalpha and IL-6 by CpG-activated PDC. These effects were associated with the inhibition of IFN Regulatory Factor (IRF)-7 nuclear translocation. Furthermore, TSA was also effective in inhibiting the production of IFNalpha by PDC cultured in vitro in the presence of serum obtained from SLE patients. This study describes a new level of regulation of immune responses by histone deacetylase inhibitors and defines the molecular basis for new strategies to be exploited in the treatment of autoimmune diseases. |
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Authors:
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Valentina Salvi; Daniela Bosisio; Stefania Mitola; Laura Andreoli; Angela Tincani; Silvano Sozzani |
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Publication Detail:
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Type: Journal Article Date: 2010-06-04 |
Journal Detail:
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Title: Immunobiology Volume: 215 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 756-61 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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