| Trichostatin Analogues JBIR-109, JBIR-110, and JBIR-111 from the Marine Sponge-Derived Streptomyces sp. RM72. | |
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MedLine Citation:
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PMID: 22276693 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Three new trichostatin analogues, JBIR-109 (1), JBIR-110 (2), and JBIR-111 (3), were isolated from the culture of the marine sponge-derived Streptomyces sp. strain RM72, together with trichostatin A (4) and trichostatic acid (5). The planar structures of 1-3 were determined on the basis of extensive NMR and MS analyses. In addition, the absolute configurations of the amino acid residues were determined by Marfey's method. The histone deacetylase inhibitory activities of 1-5 were examined, and their structure-activity relationships are discussed. |
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Authors:
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Takahiro Hosoya; Takatsugu Hirokawa; Motoki Takagi; Kazuo Shin-Ya |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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