Document Detail

Trichosporon beigelii: a life-threatening pathogen in immunocompromised hosts.
MedLine Citation:
PMID:  10745260     Owner:  NLM     Status:  MEDLINE    
Patients undergoing bone marrow transplantation are profoundly immunosuppressed as a result of their intensive myeloablative chemotherapy and are at high risk for opportunistic fungal infections mainly caused by Candida spp and Aspergillus spp. Trichosporon beigelii (T beigelii) has emerged as a life-threatening opportunistic pathogen in granulocytopenic and immunocompromised hosts and there is a marked increase in cases reported in the literature. Response to antifungal agents is poor, mortality is high and immunological recovery is the most important factor for a favorable outcome in patients with trichosporonosis. We present three cases of T. beigelii infection in patients undergoing allogeneic bone marrow transplantation in our center and we review cases described in the literature.
B Erer; M Galimberti; G Lucarelli; C Giardini; P Polchi; D Baronciani; D Gaziev; E Angelucci; G Izzi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  25     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-12     Completed Date:  2000-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  745-9     Citation Subset:  IM    
Divisione di Ematologia e Centro Trapianti Midollo Osseo di Muraglia, Pesaro, Italy.
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MeSH Terms
Bone Marrow Transplantation / adverse effects,  immunology*
Critical Illness
Graft vs Host Disease
Immunocompromised Host*
Leukemia-Lymphoma, Adult T-Cell / therapy
Mycoses / etiology*,  immunology
Transplantation, Homologous
Trichosporon* / pathogenicity
beta-Thalassemia / therapy

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