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Trichosanthin down-regulates Notch signaling and inhibits proliferation of the nasopharyngeal carcinoma cell line CNE2 in vitro.
MedLine Citation:
PMID:  22808524     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The prognosis of nasopharyngeal carcinoma (NPC) is still poor. Trichosanthin (TCS) has abortifacient, anti-virus, immunoregulation and various anti-tumor pharmacological activities, but there are no reports about its effect on NPC and the exact mechanisms that TCS inhibits tumor are not well known. In this study, the proliferation, apoptosis and soft agar colony formation abilities of CNE2 cells were examined with various assays in vitro followed by treatment with TCS. Furthermore, the activation status of Notch signaling pathway in TCS and control cells also was examined. The results revealed that TCS could inhibit NPC cell line CNE2 in vitro, reduce clone formation ability and induce apoptosis of CNE2 cells. Down-regulation of Notch signaling may be one of the mechanisms that TCS inhibits NPC.
Authors:
Fenye Liu; Bing Wang; Zhixue Wang; Shudong Yu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fitoterapia     Volume:  83     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  838-42     Citation Subset:  IM    
Affiliation:
Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, PR China.
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