Document Detail


Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention.
MedLine Citation:
PMID:  17143809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Trichomonas vaginalis causes a common sexually transmitted infection (STI) in women, yet trichomoniasis in male sexual partners is not well recognized. Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture. METHODS: We conducted a prospective, multicenter study to evaluate T. vaginalis infection among male partners of women with trichomoniasis and factors associated with infection by recruiting patients from 3 public clinics in the United States. Male partners were tested for concordant T. vaginalis infection, defined as a positive urethral culture, urine culture, or urine polymerase chain reaction (PCR) result. A subset of men also provided a semen sample for T. vaginalis culture and PCR. Factors associated with concordant infection were determined from bivariable and multivariable analyses. RESULTS: We enrolled 540 women with trichomoniasis (diagnosed using wet mount microscopy and/or culture) and 261 (48.4%) of their male partners. T. vaginalis infection was detected in 177 (71.7%) of 256 male partners (95% confidence interval [CI], 66.0%-77.3%), of whom 136 (77.3%) were asymptomatic. A vaginal pH of >4.5 in a woman was independently associated with infection in the male partner (adjusted odds ratio, 2.5; 95% CI, 1.0-6.3). Younger male age (20-29 and 30-39 years) was also found to be an independent risk factor for concordant trichomoniasis. CONCLUSIONS: The majority of male partners of women with trichomoniasis were infected; however, few factors predicted infection. T. vaginalis causes a highly prevalent STI, necessitating vastly improved partner management, application of sensitive nucleic-acid based testing, and better clinical recognition.
Authors:
Arlene C Seña; William C Miller; Marcia M Hobbs; Jane R Schwebke; Peter A Leone; Heidi Swygard; Julius Atashili; Myron S Cohen
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2006-11-27
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  44     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-01-12     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. idrod@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Culture Media
DNA, Protozoan / analysis
Female
Humans
Male
Middle Aged
Polymerase Chain Reaction
Prevalence
Semen / parasitology
Sexual Partners*
Sexually Transmitted Diseases* / diagnosis,  epidemiology,  parasitology,  prevention & control
Trichomonas Infections* / diagnosis,  epidemiology,  parasitology,  prevention & control
Trichomonas Vaginitis* / diagnosis,  epidemiology,  parasitology,  prevention & control
Trichomonas vaginalis / genetics,  isolation & purification*
Urethra / parasitology
Urine / parasitology
Vaginal Smears
Grant Support
ID/Acronym/Agency:
N01AI075329/AI/NIAID NIH HHS; U19AI031496/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media; 0/DNA, Protozoan
Comments/Corrections
Comment In:
Clin Infect Dis. 2007 Jan 1;44(1):23-5   [PMID:  17143810 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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