Document Detail

Trichoblastoma with apocrine and sebaceous differentiation.
MedLine Citation:
PMID:  15677969     Owner:  NLM     Status:  MEDLINE    
Trichoblastoma is a rare, benign tumor that differentiates toward the hair germ, the embryonic precursor of a hair follicle. Several cases of trichoblastoma showed multiple differentiation toward more than one type of adnexal structure. We report a case of a trichoblastoma, which had developed on the scalp as a solitary 1-cm nodule 3 years ago. A histologic examination indicated that the specimen had features of multiple differentiation. In particular, there were occasional foci of decapitation secretion, as well as cells with web-like and bubbly cytoplasm suggesting seboblasts, and a sebaceous duct-like structure. In addition, there were occasional germinative cells in the palisade, and scattered hair papilla-like structures showing follicular differentiation. An immunohistochemical study showed that the neoplasm, or areas in it, stained positive for low molecular cytokeratin, high molecular cytokeratin, EMA, S-100, and GCDFP-15. This is an unusual case of a trichoblastoma with apocrine and sebaceous differentiation.
Dong Kee Yu; Young Hyun Joo; Kwang Hyun Cho
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  27     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-28     Completed Date:  2005-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-8     Citation Subset:  IM    
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
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MeSH Terms
Apocrine Glands / metabolism,  pathology*
Cell Transformation, Neoplastic
Hair Diseases / metabolism,  pathology*
Hair Follicle / metabolism,  pathology*
Middle Aged
Neoplasms, Adnexal and Skin Appendage / metabolism,  pathology*,  surgery
Sebaceous Glands / metabolism,  pathology*
Treatment Outcome
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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