| Trichloroethylene induced vitamin B(12) and folate deficiency leads to increased formic acid excretion in the rat. | |
| | |
MedLine Citation:
|
PMID: 10814845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Exposure of rats to trichloroethylene induces a sustained excretion of large amounts of formic acid in urine. Both of the major metabolites, trichloroethanol and trichloroacetic acid, were found to induce this response, but not the minor metabolite S-(1, 2-dichlorovinyl) cysteine. Other polychlorinated solvents, including carbon tetrachloride and chloroform, also increased urinary formate excretion. Addition of folic acid either to diet or drinking water modulated the response indicating that these rats were folate deficient. Two markers of vitamin B(12) deficiency, methylmalonic acid and 5-methyltetrahydrofolate, were also markedly increased in urine and plasma respectively. The increase in 5-methyltetrahydrofolate is consistent with a folate deficiency caused by an inhibition of the vitamin B(12) dependent methionine salvage pathway. Since both vitamin B(12) and chemicals containing polychlorinated carbon atoms readily form free radicals, it is suggested that trichloroacetic acid and trichloroethanol interact with vitamin B(12) through a free radical mechanism inducing a B(12) deficiency and, as a consequence, a folate deficiency. As a result of the folate deficiency, excess formic acid, which is normally utilised through this pathway, is excreted in urine. |
| | |
Authors:
|
J L Dow; T Green |
Related Documents
:
|
3227495 - Changes with gestational age in the nutritional requirements of postimplantation rat em... 23614295 - Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 10746355 - Brain function in the elderly: role of vitamin b12 and folate. 12797745 - Turkish tombul hazelnut (corylus avellana l.). 1. compositional characteristics. 11708055 - Simultaneous detection of cholyl adenylate and coenzyme a thioester utilizing liquid ch... 2902505 - The expression of mutant pilins in pseudomonas aeruginosa: fifth position glutamate aff... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Toxicology Volume: 146 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 2000 May |
Date Detail:
|
Created Date: 2000-07-17 Completed Date: 2000-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0361055 Medline TA: Toxicology Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 123-36 Citation Subset: IM |
Affiliation:
|
Zeneca, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthetics, Inhalation
/
pharmacokinetics,
toxicity* Animals Bacteria / drug effects, metabolism Biotransformation Catalase / antagonists & inhibitors, metabolism Folic Acid Deficiency / chemically induced* Formic Acids / urine* Magnetic Resonance Spectroscopy Male Rats Rats, Inbred F344 Solvents / pharmacokinetics, toxicity* Trichloroethylene / pharmacokinetics, toxicity* Vitamin B 12 Deficiency / chemically induced* |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Inhalation; 0/Formic Acids; 0/Solvents; 64-18-6/formic acid; 79-01-6/Trichloroethylene; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced expression of rat hepatic microsomal epoxide hydrolase by methylthiazole in conjunction wit...
Next Document: Developmental lead exposure disturbs expression of synaptic neural cell adhesion molecules in herrin...