Document Detail


Trichloroethylene-contaminated drinking water and congenital heart defects: a critical analysis of the literature.
MedLine Citation:
PMID:  16181768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The organic solvent trichloroethylene (TCE) is a metal degreasing agent and an intermediate in the production of fluorochemicals and polyvinyl chloride. TCE is also a common, persistent drinking water contaminant. Several epidemiological studies have alleged links between TCE exposure during pregnancy and offspring health problems including congenital heart defects (CHDs); however, the results of these studies are inconsistent, difficult to interpret, and involve several confounding factors. Similarly, the results of animal studies examining the potential of TCE to elicit cardiac anomalies have been inconsistent, and they have often been performed at doses far exceeding the highest levels ever reported in the drinking water. To determine what is known about the relationship between TCE and the incidence of CHDs, a comprehensive analysis of all available epidemiological data and animal studies was performed. Additionally, in vivo and in vitro studies examining possible mechanisms of action for TCE were evaluated. The specific types of heart defects alleged to have been caused by TCE in animal and human epidemiology studies were categorized by the morphogenetic process responsible for the defect in order to determine whether TCE might disrupt any specific developmental process. This analysis revealed that no single process was clearly affected by TCE, providing support that gestational TCE exposure does not increase the prevalence of CHDs. As a final evaluation, application of Hill's causality guidelines to the collective body of data revealed no indication of a causal link between gestational TCE exposure at environmentally relevant concentrations and CHDs.
Authors:
Rebecca E Watson; Catherine F Jacobson; Amy Lavin Williams; W Brian Howard; John M DeSesso
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-09-21
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  21     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-47     Citation Subset:  IM    
Affiliation:
Mitretek Systems, 3150 Fairview Park Drive, Falls Church, VA 22033, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Female
Heart / drug effects,  growth & development
Heart Defects, Congenital / chemically induced*,  epidemiology*
Humans
Pregnancy
Solvents / toxicity*
Trichloroethylene / toxicity*
Water Pollutants, Chemical / toxicity*
Water Supply / analysis*
Chemical
Reg. No./Substance:
0/Solvents; 0/Water Pollutants, Chemical; 79-01-6/Trichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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