| Trichinella spiralis infection rapidly induces lung inflammatory response The lung as the site of helminthocytotoxic activity. | |
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MedLine Citation:
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PMID: 21411179 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the present work, we studied the kinetics of the appearance of different immunological parameters in the lungs during the intestinal phase of infection with Trichinella spiralis. We also evaluated the lung's role in the retention and death of this helminth in its migratory stage. To study these parameters, we used lung extracts, lung cell suspensions and rat lung tissue sections. During the intestinal phase of infection (days 0-13 post-infection, p.i.), an inflammatory response is elicited in the lungs, which reflects humoral, cellular and functional changes. These changes included an increased number of mast cells and eosinophils and the local production of IL-4, IL-5, IL-10, TNFα, IFNγ, IL-13, CCL11 and CCL28. We found hyperplasia of the bronchus-associated lymphoid tissue (BALT). Total and specific IgA, IgE, IgG1 and IgG2a were detected locally. The retention of the migratory larvae in the lung, together with the ex vivo cytotoxic capacity of the lung cells and antibodies present in the lung extracts, suggested that the lung was one of the immune defense organs against the pathogen's migration stage. |
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Authors:
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María V Gentilini; Guillermo G Nuñez; María E Roux; Stella M Venturiello |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: Immunobiology Volume: - ISSN: 1878-3279 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
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Microbiology, Immunology and Biotechnology Department, School of Pharmacy and Biochemistry, University of Buenos Aires, IDEHU-CONICET, Buenos Aires, Argentina. |
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