Document Detail

Trichinella isolates: parasite variability and host responses.
MedLine Citation:
PMID:  8818727     Owner:  NLM     Status:  MEDLINE    
The genus Trichinella has the widest geographical distribution and the largest range of host species of all parasitic nematodes. It remains a significant human pathogen. More than 300 isolates of the genus are now available for laboratory study. The taxonomy of the genus, which has only recently achieved some stability, depends upon the use of a variety of biological, biochemical and genetic criteria. The biological characteristics of isolates, particularly those relating to infectivity and pathogenicity, can show considerable variation because they are subject to strong host influences, notably those associated with immune and inflammatory responses. Comparative studies of different isolates in different hosts, particularly strains of inbred mice, have helped to define these influences and to identify the relative contributions of isolate immunogenicity and host immune response capacity to the outcome of infection. Data from such studies can not only contribute to a better understanding of the biology of this genus but can also throw light on fundamental aspects of host-parasite interactions.
D Wakelin; P K Goyal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal for parasitology     Volume:  26     ISSN:  0020-7519     ISO Abbreviation:  Int. J. Parasitol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-12     Completed Date:  1996-11-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0314024     Medline TA:  Int J Parasitol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  471-81     Citation Subset:  IM    
Department of Life Science, University of Nottingham, U.K.
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MeSH Terms
Antibodies, Helminth / biosynthesis
Genetic Variation
Mice, Inbred Strains
T-Lymphocytes / immunology
Trichinella / classification,  immunology,  isolation & purification*
Trichinellosis / etiology,  immunology
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Antibodies, Helminth

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