Document Detail


Trichinella: differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production.
MedLine Citation:
PMID:  16959431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with respect to their developmental strategies. Little is known at the molecular level about parasite-derived mediators responsible for host muscle cell transformation occurring during trichinellosis. In this context, host-parasite relationships in Trichinella-infected animals could be related to different host-immune and cell mediators, e.g. nitric oxide (NO). Here, we investigate the stimulatory/inhibitory role of L1 antigens from four encapsulated (T. spiralis, T. britovi, T. nelsoni and T. nativa) and one non-encapsulated (T. pseudospiralis) Trichinella species on NO production from rat macrophages in vitro. Our results demonstrate that encapsulated and non-encapsulated Trichinella species differ in their capacity to stimulate the secretion of NO from host macrophages. Biological significance of these differences should be further assessed in the available experimental models.
Authors:
M Amparo Andrade; Mar Siles-Lucas; Julio López-Abán; Juan José Nogal-Ruiz; José Luis Pérez-Arellano; Antonio R Martínez-Fernández; Antonio Muro
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-07
Journal Detail:
Title:  Veterinary parasitology     Volume:  143     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-03-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Affiliation:
Laboratorio de Inmunología Parasitaria y Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro, s/n 37007, Salamanca, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Helminth / immunology*
Cells, Cultured
Genotype
Host-Parasite Interactions
Humans
Intestinal Diseases, Parasitic / immunology,  parasitology,  veterinary
Macrophages, Alveolar / metabolism*
Nitric Oxide / biosynthesis*
Rats
Species Specificity
Trichinella / immunology*
Trichinellosis / immunology,  parasitology,  veterinary*
Chemical
Reg. No./Substance:
0/Antigens, Helminth; 10102-43-9/Nitric Oxide

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