Document Detail

Trichinella: differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production.
MedLine Citation:
PMID:  16959431     Owner:  NLM     Status:  MEDLINE    
Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with respect to their developmental strategies. Little is known at the molecular level about parasite-derived mediators responsible for host muscle cell transformation occurring during trichinellosis. In this context, host-parasite relationships in Trichinella-infected animals could be related to different host-immune and cell mediators, e.g. nitric oxide (NO). Here, we investigate the stimulatory/inhibitory role of L1 antigens from four encapsulated (T. spiralis, T. britovi, T. nelsoni and T. nativa) and one non-encapsulated (T. pseudospiralis) Trichinella species on NO production from rat macrophages in vitro. Our results demonstrate that encapsulated and non-encapsulated Trichinella species differ in their capacity to stimulate the secretion of NO from host macrophages. Biological significance of these differences should be further assessed in the available experimental models.
M Amparo Andrade; Mar Siles-Lucas; Julio López-Abán; Juan José Nogal-Ruiz; José Luis Pérez-Arellano; Antonio R Martínez-Fernández; Antonio Muro
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-07
Journal Detail:
Title:  Veterinary parasitology     Volume:  143     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-03-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Laboratorio de Inmunología Parasitaria y Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro, s/n 37007, Salamanca, Spain.
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MeSH Terms
Antigens, Helminth / immunology*
Cells, Cultured
Host-Parasite Interactions
Intestinal Diseases, Parasitic / immunology,  parasitology,  veterinary
Macrophages, Alveolar / metabolism*
Nitric Oxide / biosynthesis*
Species Specificity
Trichinella / immunology*
Trichinellosis / immunology,  parasitology,  veterinary*
Reg. No./Substance:
0/Antigens, Helminth; 10102-43-9/Nitric Oxide

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