Document Detail


Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
MedLine Citation:
PMID:  15657476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine whether ingestion of a multinutrient supplement containing 3 tricarboxylic-acid-cycle intermediates (TCAIs; pyridoxine-alpha-ketoglutarate, malate, and succinate) and other substances potentially supporting the TCA cycle (such as aspartate and glutamate) would improve cyclists' time to exhaustion during a submaximal endurance-exercise test (approximately 70 % to 75 % VO2peak) and rate of recovery. Seven well-trained male cyclists (VO2max 67.4 2.1 mL x kg(-1) x in(-1), 28.6 +/- 2.4 y) participated in a randomized, double-blind crossover study for 7 wk. Each took either the treatment or a placebo 30 min before and after their normal training sessions for 3 wk and before submaximal exercise tests. There were no significant differences between the TCAI group (KI) and placebo group (P) in time to exhaustion during cycling (KI = 105 +/- 18, P = 113 +/- 11 min); respiratory-exchange ratio at 20-min intervals; blood lactate and plasma glucose before, after, and at 30-min intervals during exercise; perceived exertion at 20-min intervals during exercise; or time to fatigue after the 30-min recovery (KI = 16.1 +/- 3.2, P = 15 +/- 2 min). Taking a dietary sport supplement containing several TCAIs and supporting substances for 3 wk does not improve cycling performance at 75 % VO2peak or speed recovery from previously fatiguing exercise.
Authors:
Amy C Brown; Holden S H Macrae; Nathan S Turner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  14     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-19     Completed Date:  2005-06-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-9     Citation Subset:  IM    
Affiliation:
Dept of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / administration & dosage*,  metabolism
Bicycling / physiology*
Citric Acid Cycle / physiology*
Cross-Over Studies
Dietary Supplements*
Double-Blind Method
Exercise Test
Heart Rate / drug effects,  physiology
Humans
Male
Oxygen Consumption
Physical Endurance / drug effects,  physiology*
Physical Exertion / drug effects,  physiology
Time Factors
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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