| Triazenoindazoles and triazenopyrazolopyridines: design, synthesis, and cytotoxic activity. | |
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MedLine Citation:
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PMID: 20607485 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Several triazenoindazoles 3a-e and triazinopyrazolopyridines 6a-i were prepared through the reaction of the corresponding 3-amino-4-chloroindazole and 3-aminopyrazolopyridine diazonium salts 2 and 5 with a number of secondary amines. All compounds were evaluated for their in vitro cytotoxic activity on three cell lines, HepG2, MCF7, and HeLa. Most compounds inhibited cell growth with IC(50) less than 0.1 microM. Compound 6d was the most potent, with an IC(50) of 0.03 microM against HepG2 and 0.05 microM against MCF7 and HeLa cells. |
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Authors:
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Maha Abdel-Hakeem |
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Publication Detail:
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Type: Journal Article Date: 2010-07-06 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 33 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 813-9 Citation Subset: IM |
Affiliation:
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Pharmaceutical Organic Chemistry Department, Cairo University, Cairo, 11562, Egypt. Mahaabdelhakim_12@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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