Document Detail


Triamcinolone acetonide without solvents.
MedLine Citation:
PMID:  23021229     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The purification of commercially prepared triamcinolone acetonide is important in order to avoid the potential toxic side-effects of the solvent benzyl alcohol. We present a new technique for preparation of pure triamcinolone acetonide by dissolving the powder in sterile distilled water with no additional solvents. As the triamcinolone powder is relatively insoluble in water, we describe the sterile method used for the preparation and control of this suspension. MATERIALS AND METHODS: The triamcinolone acetonide is prepared in our hospital pharmacy, under optimum sterile conditions, and then packaged in a primary vial, sealed and sterilized in an autoclave at 121°C. This vial contains an individual dose of 4mg/0.1ml. RESULTS: A final dose for an intravitreal administration of 3.77mg/0.1ml triamcinolone acetonide was obtained using high pressure liquid chromatography (HPLC). The chemical, physical and microbiological stability allows the solution to be kept at a temperature of 2-8°C for 6 months. CONCLUSIONS: A rapid method is presented for preparing triamcinolone acetonide in pure state without preservatives in a concentration near the standard dose and under optimum sterile conditions.
Authors:
M Martínez Rubio; M Moya Moya; J Selva Otaola-Urruchi; T Martínez Lazcano; J Belmonte Martínez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-30
Journal Detail:
Title:  Archivos de la Sociedad Espanola de Oftalmologia     Volume:  87     ISSN:  1989-7286     ISO Abbreviation:  Arch Soc Esp Oftalmol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1304603     Medline TA:  Arch Soc Esp Oftalmol     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  320-323     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.
Affiliation:
Servicio de Oftalmología, Hospital General Universitario Alicante, Alicante, España. Electronic address: martinez_magrub@gva.es.
Vernacular Title:
Acetónido de triamcinolona sin conservantes.
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