Document Detail

Trials of lithium, chlorpromazine and amitriptyline in schizoaffective patients.
MedLine Citation:
PMID:  354733     Owner:  NLM     Status:  MEDLINE    
Two drug trials in schizoaffective patients are reported. Nineteen "schizomanic" patients were treated for one month, on a double blind basis, with chlorpromazine or lithium and 41 "schizodepressive" patients with amitriptyline, chlorpromazine or both. In the schizodepressive patients there was a trend to a better response to chlorpromazine, but drug response generally was poor, only 20 per cent of patients recovering within the month. In the schizomanic patients lithium seemed as effective as chlorpromazine, which supports the view that these patients were suffering from a variant of mania.
I F Brockington; R E Kendell; J M Kellett; S H Curry; S Wainwright
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  133     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
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MeSH Terms
Amitriptyline / therapeutic use*
Chlorpromazine / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Lithium / therapeutic use*
Schizophrenia / drug therapy*
Schizophrenic Psychology
Reg. No./Substance:
50-48-6/Amitriptyline; 50-53-3/Chlorpromazine; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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