Document Detail

Trials in surgery.
MedLine Citation:
PMID:  14716788     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Trials in surgery pose some special problems. This paper examines these with reference to 10 years of methodological research sponsored by the UK National Health Service Research and Development programme. METHODS: Solutions to common problems encountered in surgical studies were considered, such as issues of blinding, dependence of results on technical skill and continued evolution of technology. RESULTS: Numerous methodological developments are described, including the tracker trial concept in which trial design can be adapted to take account of technical developments and interim results. The governance of trials, solutions to ethical conundra and the rising importance of databases are also discussed. CONCLUSION: Like surgery itself, the methodological toolkit for evaluation of surgical procedures continues to evolve. The rules of statistical and scientific probity provide plenty of scope for imaginative design solutions for surgical trials.
R Lilford; D Braunholtz; J Harris; T Gill
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of surgery     Volume:  91     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-12     Completed Date:  2004-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-16     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2003 British Journal of Surgery Society Ltd.
Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
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MeSH Terms
Bias (Epidemiology)
Ethics, Medical
Evidence-Based Medicine
Patient Satisfaction
Patient Selection
Randomized Controlled Trials as Topic / ethics,  methods*
Sample Size
Sensitivity and Specificity
Surgical Procedures, Operative / ethics,  methods*
Time Factors
Treatment Outcome

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