| A trial to assess the efficacy of glutamic acid in prevention of vincristine-induced neurotoxicity in pediatric malignancies: a pilot study. | |
| | |
MedLine Citation:
|
PMID: 20921909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Vincristine is considered as a backbone of therapy in the induction and consolidation phases of pediatric malignancies. Neurotoxicity is a principal side effect of its use. This study is a randomized single-blinded placebo-controlled clinical trial to evaluate the role of glutamic acid in ameliorating neurotoxicity in pediatric patients with hematologic and solid tumors receiving vincristine during induction course. Fifty-four patients in the glutamic acid group received glutamic acid 1.5 grams daily orally in 3 divided doses during the 4-week induction with vincristine in a dose of 1.5 mg/m² IV weekly. Placebo group (40 patients) received oral placebo 3 times daily in the same way as the glutamic acid group. The onset of neurotoxicity was significantly earlier in placebo group than in glutamic acid group regarding tendon Achilles reflex, Patellar reflex, parasthesia, and increased frequency of constipation. This was statistically significant mostly in third and fourth visits, no severe cases of strength and mental alteration side effects in both groups. Glutamic acid was well tolerated with no gastrointestinal side effects in patients. This study suggests that the coadministration of oral glutamic acid with repetitive intravenous bolus injections of vincristine resulted in a reduction of its neurotoxicity. |
| | |
Authors:
|
Galila M Mokhtar; Sanaa Y Shaaban; Nancy Samir Elbarbary; Waleed A Fayed |
Related Documents
:
|
19722489 - Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzner... 10078989 - Effects of bilobalide on gamma-aminobutyric acid levels and glutamic acid decarboxylase... 15331039 - Detection of amino acid and peptide transmitters in physiologically identified brainste... 1358849 - N-alkoxycarbonyl-glutamic and aspartic acids. studies on the activation and cyclodehydr... 4528109 - Vitamin k dependent modifications of glutamic acid residues in prothrombin. 2902859 - Influence of cold exposure on liver amino acid metabolism enzymes of the rat. 22180549 - Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy. 11760999 - Unusually high levels of non-saponifiable lipids in the fishes escolar and rudderfish i... 2260339 - Excipients in valproic acid syrup may cause diarrhea: a case report. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-27 Completed Date: 2010-11-16 Revised Date: 2011-10-06 |
Medline Journal Info:
|
Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
|
Languages: eng Pagination: 594-600 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Antineoplastic Agents, Phytogenic / administration & dosage, adverse effects* Child Child, Preschool Cognition / drug effects Constipation / chemically induced, prevention & control Drug Interactions Female Glutamic Acid / administration & dosage* Humans Kidney Neoplasms / drug therapy Lymphoma, Non-Hodgkin / drug therapy Male Muscle Strength / drug effects Nervous System Diseases / chemically induced*, prevention & control* Paresthesia / chemically induced, prevention & control Pilot Projects Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Reflex, Stretch / drug effects Vincristine / administration & dosage, adverse effects* Wilms Tumor / drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 56-86-0/Glutamic Acid; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reduced methotrexate clearance and renal impairment in a boy with osteosarcoma and earlier undetecte...
Next Document: Prevalence of valvular regurgitation in adolescent idiopathic scoliosis patients.