Document Detail

A trial to assess the efficacy of glutamic acid in prevention of vincristine-induced neurotoxicity in pediatric malignancies: a pilot study.
MedLine Citation:
PMID:  20921909     Owner:  NLM     Status:  MEDLINE    
Vincristine is considered as a backbone of therapy in the induction and consolidation phases of pediatric malignancies. Neurotoxicity is a principal side effect of its use. This study is a randomized single-blinded placebo-controlled clinical trial to evaluate the role of glutamic acid in ameliorating neurotoxicity in pediatric patients with hematologic and solid tumors receiving vincristine during induction course. Fifty-four patients in the glutamic acid group received glutamic acid 1.5 grams daily orally in 3 divided doses during the 4-week induction with vincristine in a dose of 1.5 mg/m² IV weekly. Placebo group (40 patients) received oral placebo 3 times daily in the same way as the glutamic acid group. The onset of neurotoxicity was significantly earlier in placebo group than in glutamic acid group regarding tendon Achilles reflex, Patellar reflex, parasthesia, and increased frequency of constipation. This was statistically significant mostly in third and fourth visits, no severe cases of strength and mental alteration side effects in both groups. Glutamic acid was well tolerated with no gastrointestinal side effects in patients. This study suggests that the coadministration of oral glutamic acid with repetitive intravenous bolus injections of vincristine resulted in a reduction of its neurotoxicity.
Galila M Mokhtar; Sanaa Y Shaaban; Nancy Samir Elbarbary; Waleed A Fayed
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  32     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-11-16     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-600     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Antineoplastic Agents, Phytogenic / administration & dosage,  adverse effects*
Child, Preschool
Cognition / drug effects
Constipation / chemically induced,  prevention & control
Drug Interactions
Glutamic Acid / administration & dosage*
Kidney Neoplasms / drug therapy
Lymphoma, Non-Hodgkin / drug therapy
Muscle Strength / drug effects
Nervous System Diseases / chemically induced*,  prevention & control*
Paresthesia / chemically induced,  prevention & control
Pilot Projects
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Reflex, Stretch / drug effects
Vincristine / administration & dosage,  adverse effects*
Wilms Tumor / drug therapy
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 56-86-0/Glutamic Acid; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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