| Trial of combination of guanethidine and oxprenolol in hypertension. | |
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MedLine Citation:
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PMID: 773486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen hypertensive patients entered a double-blind crossover trial of guanethidine and oxprenolol in combination. In nine patients who completed the trial there was an additive effect on blood pressure, but the combination had a smaller effect on heart rate than was expected from the individual effects, and side effects were not increased. During treatment with oxprenolol the plasma potassium concentration rose from 3.6 mmol (mEq)/1 to 3.9 mmol (mEq)/1. No correlation was found between the plasma oxprenolol concentration and changes in blood pressure or response to injected isoprenaline, but measurements of plasma oxprenolol concentrations were of value in determining compliance with the protocol. |
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Authors:
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R M Pearson; M R Bending; C J Bulpitt; C F George; D R Hole; F M Williams; A M Breckenridge |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British medical journal Volume: 1 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1976 Apr |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 933-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Clinical Trials as Topic Drug Therapy, Combination Female Guanethidine / adverse effects, therapeutic use* Heart Rate / drug effects Humans Hypertension / drug therapy* Male Oxprenolol / adverse effects, blood, therapeutic use* Placebos Potassium / blood Serum Albumin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 0/Serum Albumin; 55-65-2/Guanethidine; 6452-71-7/Oxprenolol; 7440-09-7/Potassium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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