Document Detail


Trial of Edmonston-Zagreb measles vaccine in infants aged under nine months.
MedLine Citation:
PMID:  1818384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to the recent finding that most infants in developing countries have lost maternal antibody for measles before nine months of age, immunization of infants younger than the recommended age of nine months would help reducing the incidence of measles in these endemic areas. We conducted a trial of Edmonston-Zagreb measles vaccine which is the strain that may be more immunogenic in young infants than the widely used Schwarz strain. Forty-five infants with mean age of 25 weeks received a dose of Edmonston-Zagreb vaccine. Antibody levels were measured, using plaque neutralization test, before and about 3 months after vaccination at which mean age was 38 weeks. The seroconversion rate was 89%. Only two infants (4.4%) had immunity before vaccination. Fifteen infants (33.33%) reported some adverse reactions including fever (13.33%), rhinorrhea (8.89%), rash (4.44%) and local reactions (22.22%). All of the reactions resolved spontaneously. We conclude that Edmonston-Zagreb measles vaccine is efficacious and safe in infants aged under nine months.
Authors:
V Pongrithsukda; R Gluck; S Suwatanapongched; P Kaewmalung; J Muyakul
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  22     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-07-16     Completed Date:  1992-07-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  347-50     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Maharaj Nakhon Ratchasima Hospital, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Female
Humans
Immunity, Active
Immunity, Maternally-Acquired
Incidence
Infant
Male
Measles / blood,  epidemiology,  prevention & control*
Measles Vaccine / administration & dosage,  adverse effects,  therapeutic use*
Neutralization Tests
Thailand / epidemiology
Chemical
Reg. No./Substance:
0/Measles Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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