| Triacylglycerol lipases and metabolic control: implications for health and disease. | |
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MedLine Citation:
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PMID: 20071561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during physical activity. This review outlines the identification of the new TG lipase, adipose triglyceride lipase, the current understanding of how cellular TG lipases are regulated, and the implications for understanding the integrated control of TG lipolysis. Furthermore, this review outlines recent advances that propose a "revised" role for TG lipases in cellular function, metabolic homeostasis, and disease prevention. |
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Authors:
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Matthew J Watt; Lawrence L Spriet |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-13 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 299 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E162-8 Citation Subset: IM |
Affiliation:
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Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria 3800, Australia. matthew.watt@med.monash.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease* Fatty Acids / metabolism Gene Expression Regulation, Enzymologic / physiology Health* Humans Lipase / genetics, metabolism* Lipolysis / genetics, physiology Metabolism / physiology* Mitochondria / enzymology, physiology Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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