Document Detail

Triacylglycerol biosynthesis in yeast.
MedLine Citation:
PMID:  12743757     Owner:  NLM     Status:  MEDLINE    
Triacylglycerol (TAG) is the major storage component for fatty acids, and thus for energy, in eukaryotic cells. In this mini-review, we describe recent progress that has been made with the yeast Saccharomyces cerevisiae in understanding formation of TAG and its cell biological role. Formation of TAG involves the synthesis of phosphatidic acid (PA) and diacylglycerol (DAG), two key intermediates of lipid metabolism. De novo formation of PA in yeast as in other types of cells can occur either through the glycerol-3-phosphate- or dihydroxyacetone phosphate-pathways-each named after its respective precursor. PA, formed in two steps of acylation, is converted to DAG by phosphatidate phosphatase. Acylation of DAG to yield TAG is catalyzed mainly by the two yeast proteins Dga1p and Lro1p, which utilize acyl-CoA or phosphatidylcholine, respectively, as acyl donors. In addition, minor alternative routes of DAG acylation appear to exist. Endoplasmic reticulum and lipid particles (LP), the TAG storage compartment in yeast, are the major sites of TAG synthesis. The interplay of these organelles, formation of LP, and enzymatic properties of enzymes catalyzing the synthesis of PA, DAG, and TAG in yeast are discussed in this communication.
D Sorger; G Daum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2003-01-29
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  61     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-13     Completed Date:  2003-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  289-99     Citation Subset:  IM    
Institut für Biochemie, Technische Universität Graz, Petersgasse 12/2, Austria.
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MeSH Terms
Acyltransferases / metabolism
Diacylglycerol O-Acyltransferase
Diglycerides / metabolism
Endoplasmic Reticulum / metabolism
Organelles / metabolism
Phosphatidic Acids / biosynthesis
Saccharomyces cerevisiae / enzymology,  metabolism*
Saccharomyces cerevisiae Proteins / metabolism
Triglycerides / biosynthesis*
Reg. No./Substance:
0/Diglycerides; 0/Phosphatidic Acids; 0/Saccharomyces cerevisiae Proteins; 0/Triglycerides; EC 2.3.-/Acyltransferases; EC O-Acyltransferase

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