| Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. | |
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MedLine Citation:
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PMID: 18243701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells. |
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Authors:
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Francisco Cuenca; Olga Greciano; Mekala Gunaratnam; Shozeb Haider; Deeksha Munnur; Rupesh Nanjunda; W David Wilson; Stephen Neidle |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-18 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 18 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-10 Completed Date: 2008-05-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 1668-73 Citation Subset: IM |
Affiliation:
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CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemistry*,
metabolism*,
pharmacology Cell Line, Tumor Fluorescence Resonance Energy Transfer G-Quadruplexes* Humans Imides Ligands Models, Molecular Molecular Structure Naphthalenes Phenanthrolines / chemistry*, metabolism*, pharmacology Telomerase / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Imides; 0/Ligands; 0/Naphthalenes; 0/Phenanthrolines; 22291-04-9/naphthalenediimide; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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