Document Detail

Tretinoin for the treatment of photodamaged skin.
MedLine Citation:
PMID:  21049767     Owner:  NLM     Status:  MEDLINE    
Interest in and interventions for photodamaged skin have dramatically increased over the last few years. Although a number of topical therapies have been used for the treatment of photodamaged skin, many therapies remain unproven in efficacy, unapproved, or only supported with limited clinical evidence. Topical retinoids, particularly tretinoin, are the most extensively studied. They have been shown to attenuate and reverse the signs of photodamage, such as coarse wrinkling. In addition, the clinical changes achieved with tretinoin are accompanied by histologic evidence of benefit. The main drawbacks to retinoid use are local irritation and erythema that can limit utility in some patients. New retinoids and formulations specifically optimized to improve cutaneous tolerability have been introduced. Two case reports of patients using low-concentration tretinoin gel 0.05% for the treatment of photodamaged skin are discussed. Over a relatively short treatment period of 4 weeks, tretinoin gel 0.05% was shown to provide both chemoprevention and reversal of photodamage.
William Ting
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  86     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-11-23     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Advanced Dermatology Care, 5801 Norris Canyon Rd, Ste 200B, San Ramon, CA 94583, USA.
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MeSH Terms
Administration, Cutaneous
Keratolytic Agents / administration & dosage,  therapeutic use*
Middle Aged
Skin Aging / drug effects*
Sunlight / adverse effects
Tretinoin / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Keratolytic Agents; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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