Document Detail


Tretinoin microsphere gel in younger acne patients.
MedLine Citation:
PMID:  18724649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Facial acne is common in adolescents and can have a significant psychosocial impact. Treatments prescribed should not add stress by causing excessive localized irritation. OBJECTIVE: To determine whether the lowest concentration of tretinoin microsphere gel (TMG) currently available (0.04%) provides an acceptable balance of efficacy and tolerability for adolescents with moderate facial acne. METHODS: The findings of 2 multicenter, randomized, double-blind, vehicle-controlled trials of TMG 0.04% applied once nightly for 12 weeks in 245 adolescents ages 11 to 16 years with moderate facial acne were combined. Patients were evaluated via changes in acne lesion counts and the occurrence of cutaneous and other adverse effects. RESULTS: Tretinoin microsphere gel 0.04% reduced total, noninflammatory, and inflammatory lesion counts to a significantly greater extent than the vehicle gel at 12 weeks (P<.000005). The mean percentage reductions in noninflammatory and inflammatory lesion counts at 12 weeks in females were 45.0% and 51.4%, respectively; and in males, 20.5% and 36.7%, respectively. Tretinoin microsphere gel 0.04% was tolerated well, with over 70% of patients experiencing no cutaneous adverse events (AEs). CONCLUSION: Tretinoin microsphere gel 0.04% is effective in significantly reducing all types of acne lesions in adolescents with moderate facial acne ages 11 to 16 years, and has a low incidence of cutaneous AEs.
Authors:
Joseph Jorizzo; Rachel Grossman; Marge Nighland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  7     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2008-12-02     Revised Date:  2009-01-24    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  s9-13     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / drug therapy*
Adolescent
Female
Gels
Humans
Keratolytic Agents / therapeutic use*
Male
Microspheres
Randomized Controlled Trials as Topic
Tretinoin / administration & dosage,  adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Gels; 0/Keratolytic Agents; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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