Document Detail

Trends of survival in neuroblastoma and independent risk factors for survival at a single institution.
MedLine Citation:
PMID:  9212844     Owner:  NLM     Status:  MEDLINE    
To assess the progress of survival in neuroblastoma which varies with many risk factors and to evaluate the influence of these factors on survival as independent risk factors. The study subjects were 159 neuroblastoma patients seen from 1965-1994 at the oldest and largest children's hospital in Japan. Trends of survival in three treatment eras-1965-81, 1982-86, 1987-94-were assessed by the Kaplan-Meier method for different sex, age at diagnosis, the clinical stage, the site of onset, and the histological type. Then the influence on survival of these factors as independent prognostic variables was evaluated by the Cox proportional hazards regression analysis. Age at diagnosis, the clinical stage, the site of onset, the histological type, and the treatment era were independent risk factors in the order of their influence on survival. Unfavorable survival outcomes were obtained for patients with age at diagnosis above 1 year, the clinical stage of VI by the Evans classification, adrenal onset, and neuroblastoma rather than ganglioneuroblastoma. Survival improved from the first to the second and from the second to the third treatment era. Improvement of survival in neuroblastoma took place during the past 3 decades. Age at diagnosis, the clinical stage, and the histological type have still remained overwhelming prognostic factors over the progress in treatment.
T Saito; Y Tsunematsu; M Saeki; T Honna; E Masaki; Y Kojima; J Miyauchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  29     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  197-205     Citation Subset:  IM    
Division of Environmental Epidemiology at the National Children's Medical Research Center, Tokyo, Japan.
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MeSH Terms
Adrenal Gland Neoplasms / mortality,  pathology
Age Factors
Child, Preschool
Ganglioneuroblastoma / mortality,  pathology
Japan / epidemiology
Multivariate Analysis
Neoplasm Staging
Neuroblastoma / mortality*,  pathology
Outcome Assessment (Health Care)
Proportional Hazards Models
Regression Analysis
Risk Factors
Sex Factors
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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