| Trends of survival in neuroblastoma and independent risk factors for survival at a single institution. | |
MedLine Citation:
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PMID: 9212844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the progress of survival in neuroblastoma which varies with many risk factors and to evaluate the influence of these factors on survival as independent risk factors. The study subjects were 159 neuroblastoma patients seen from 1965-1994 at the oldest and largest children's hospital in Japan. Trends of survival in three treatment eras-1965-81, 1982-86, 1987-94-were assessed by the Kaplan-Meier method for different sex, age at diagnosis, the clinical stage, the site of onset, and the histological type. Then the influence on survival of these factors as independent prognostic variables was evaluated by the Cox proportional hazards regression analysis. Age at diagnosis, the clinical stage, the site of onset, the histological type, and the treatment era were independent risk factors in the order of their influence on survival. Unfavorable survival outcomes were obtained for patients with age at diagnosis above 1 year, the clinical stage of VI by the Evans classification, adrenal onset, and neuroblastoma rather than ganglioneuroblastoma. Survival improved from the first to the second and from the second to the third treatment era. Improvement of survival in neuroblastoma took place during the past 3 decades. Age at diagnosis, the clinical stage, and the histological type have still remained overwhelming prognostic factors over the progress in treatment. |
Authors:
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T Saito; Y Tsunematsu; M Saeki; T Honna; E Masaki; Y Kojima; J Miyauchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical and pediatric oncology Volume: 29 ISSN: 0098-1532 ISO Abbreviation: Med. Pediatr. Oncol. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-07-31 Completed Date: 1997-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506654 Medline TA: Med Pediatr Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 197-205 Citation Subset: IM |
Affiliation:
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Division of Environmental Epidemiology at the National Children's Medical Research Center, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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mortality,
pathology Age Factors Child, Preschool Female Ganglioneuroblastoma / mortality, pathology Humans Infant Japan / epidemiology Male Multivariate Analysis Neoplasm Staging Neuroblastoma / mortality*, pathology Outcome Assessment (Health Care) Prognosis Proportional Hazards Models Regression Analysis Risk Factors Sex Factors Survival Rate Treatment Outcome |
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