Document Detail

Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis.
MedLine Citation:
PMID:  21655745     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The present study aimed to investigate the trends in changes in pulmonary function and the risk factors for pulmonary function deterioration in patients with pulmonary tuberculosis after completing treatment.
INTRODUCTION: Patients usually have pulmonary function abnormalities after completing treatment for pulmonary tuberculosis. The time course for changes in pulmonary function and the risk factors for deterioration have not been well studied.
METHODS: A total of 115 patients with 162 pulmonary function results were analyzed. We retrieved demographic and clinical data, radiographic scores, bacteriological data, and pulmonary function data. A generalized additive model with a locally weighted scatterplot smoothing technique was used to evaluate the trends in changes in pulmonary function. A generalized estimating equation model was used to determine the risk factors associated with deterioration of pulmonary function.
RESULTS: The median interval between the end of anti-tuberculosis treatment and the pulmonary function test was 16 months (range: 0 to 112 months). The nadir of pulmonary function occurred approximately 18 months after the completion of the treatment. The risk factors associated with pulmonary function deterioration included smear-positive disease, extensive pulmonary involvement prior to anti-tuberculosis treatment, prolonged anti-tuberculosis treatment, and reduced radiographic improvement after treatment.
CONCLUSIONS: After the completion of anti-tuberculosis TB treatment, several risk factors predicted pulmonary function deterioration. For patients with significant respiratory symptoms and multiple risk factors, the pulmonary function test should be followed up to monitor the progression of functional impairment, especially within the first 18 months after the completion of anti-tuberculosis treatment.
Kuei-Pin Chung; Jung-Yueh Chen; Chih-Hsin Lee; Huey-Dong Wu; Jann-Yuan Wang; Li-Na Lee; Chong-Jen Yu; Pan-Chyr Yang;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-12-28     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  549-56     Citation Subset:  IM    
Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Aged, 80 and over
Antitubercular Agents / adverse effects*,  therapeutic use
Data Collection / methods
Lung / drug effects*,  physiopathology
Middle Aged
Models, Biological
Risk Factors
Time Factors
Treatment Outcome
Tuberculosis, Pulmonary / drug therapy*,  physiopathology
Young Adult
Reg. No./Substance:
0/Antitubercular Agents
Jann-Yuan Wang / ; Li-Na Lee / ; Chong-Jen Yu / ; Pan-Chyr Yang / ; Wei-Juin Su / ; Chin-Chung Shu / ; Hsin-Chih Lai / ; Chih-Hsin Lee / ; Ming-Chih Yu / ; Vin-Cent Wu /

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