Document Detail

Trends of polycyclic aromatic hydrocarbon levels and mutagenicity in Santiago's inhalable airborne particles in the period 1992-1996.
MedLine Citation:
PMID:  11114788     Owner:  NLM     Status:  MEDLINE    
Trends of polycyclic aromatic hydrocarbons (PAHs) for 1992-1996 (cold season) and their mutagenic activity were investigated in organic extracts from the Santiago, Chile, inhalable particles (PM(10)). The highest PAH concentrations were observed in 1992 and declined dramatically in the following years. During this period, total PAHs decreased 85%, carcinogenic PAHs 82%, and benzo[a]pyrene, the most potent carcinogen, 85%. In spite of this significant decrease, PAH levels in respirable particles were higher than those reported in recent studies in Australia, Europe, and the United States. PAH profiles were analyzed by principal component (PC) analysis and Pearson correlation analysis. PC1 represents 71% of the variance, suggesting that most PAHs might originate predominantly from one main generic source. Higher correlations were obtained for the major carcinogenic PAHs. Most of the samples assayed were highly mutagenic to Salmonella typhimurium both in the presence and in the absence of metabolic activation system (S9), especially in the coarse fraction, but direct mutagenicity did not decline significantly. Incubation of calf thymus DNA with organic extracts from particulate matter and xanthine oxidase allowed the detection of five nitro-PAH-DNA adducts. Thus, nitroarenes might play an important role in the mutagenic activity of inhalable particles in Santiago, representing a high risk for human health.
L Gil; L King; M Adonis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  12     ISSN:  0895-8378     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-03     Completed Date:  2001-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1185-204     Citation Subset:  IM    
Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70087, Santiago 7, Chile.
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MeSH Terms
Administration, Inhalation
Air Pollutants / analysis*
DNA Adducts / analysis
Mutagens / analysis*
Polycyclic Hydrocarbons, Aromatic / analysis*
Rats, Sprague-Dawley
Time Factors
Reg. No./Substance:
0/Air Pollutants; 0/DNA Adducts; 0/Mutagens; 0/Polycyclic Hydrocarbons, Aromatic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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