Document Detail

Trends in prenatal screening and diagnostic testing among women referred for advanced maternal age.
MedLine Citation:
PMID:  20063323     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We evaluated the trends in uptake of amniocentesis and chorionic villi sampling (CVS) for prenatal diagnosis compared with uptake of first and second trimester prenatal serum screening for Down syndrome among patients referred for genetic counseling for advanced maternal age (AMA). METHODS: Patients referred for AMA genetic counseling from 2001 through 2008 were informed of both prenatal serum screening and invasive diagnostic testing options. Testing offered and testing decisions were entered in a computer database and uptake rates calculated for each year with trends compared using logistic regression analysis. RESULTS: From 2001 through 2007, we observed a decline in amniocentesis and CVS uptake (p = 0.0001). This trend reversed in 2008 for both invasive procedures (p = 0.0001). Uptake of prenatal serum screening increased over the study period with uptake of first trimester screening increasing 1.7 fold in 2008. CONCLUSION: Improved prenatal screening tests and increased availability of screening for AMA patients has led to a steady decline in uptake of invasive testing from 2001 through 2007. This trend reversed from 2007 through 2008. Possible reasons for this reversal are discussed.
Naomi Nakata; Yuemei Wang; Sucheta Bhatt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  198-206     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 John Wiley & Sons, Ltd.
Genzyme Genetics, Los Angeles, CA 90066, USA.
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MeSH Terms
Amniocentesis / methods,  trends*,  utilization
Chorionic Villi Sampling / methods,  trends*,  utilization
Down Syndrome / blood*,  diagnosis
Genetic Counseling
Maternal Age*
Patient Acceptance of Health Care / statistics & numerical data
Pregnancy Trimester, First / blood
Pregnancy Trimester, Second / blood
Pregnancy, High-Risk / blood*

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