Document Detail

Trends in neural tube defect prevalence, folic acid fortification, and vitamin supplement use.
MedLine Citation:
PMID:  12211618     Owner:  NLM     Status:  MEDLINE    
In this review, the authors analyze international trends in rates of neural tube defects (NTDs) during the past three decades. Population-based data sources include the Metropolitan Atlanta Congenital Defects Program and other US birth defects surveillance programs in the National Birth Defects Prevention Network, the International Clearinghouse for Birth Defects Monitoring Systems, and US and Canadian vital records. To analyze trends in vitamin consumption, we review data from the US National Health and Nutrition Examination Surveys and international surveys of multivitamin use. We discuss the role of factors associated with historic and continuing declines in NTD rates in most countries. These factors include the introduction and increased utilization of prenatal diagnosis, recommendations for multivitamin use in women of childbearing age, and population-wide increases in blood folate levels that have occurred since food fortification was mandated. We also discuss research needs for further NTD prevention. This is a US government work. There are no restrictions on its use.
Richard S Olney; Joseph Mulinare
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in perinatology     Volume:  26     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2003-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-85     Citation Subset:  IM    
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
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MeSH Terms
Canada / epidemiology
Dietary Supplements
Folic Acid / administration & dosage*,  blood,  metabolism
Food, Fortified / standards
Infant, Newborn
Neural Tube Defects / epidemiology*,  prevention & control
Population Surveillance
Prenatal Diagnosis
United States / epidemiology
Vitamins / administration & dosage*
Reg. No./Substance:
0/Vitamins; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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