| Trends in neural tube defect prevalence, folic acid fortification, and vitamin supplement use. | |
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MedLine Citation:
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PMID: 12211618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review, the authors analyze international trends in rates of neural tube defects (NTDs) during the past three decades. Population-based data sources include the Metropolitan Atlanta Congenital Defects Program and other US birth defects surveillance programs in the National Birth Defects Prevention Network, the International Clearinghouse for Birth Defects Monitoring Systems, and US and Canadian vital records. To analyze trends in vitamin consumption, we review data from the US National Health and Nutrition Examination Surveys and international surveys of multivitamin use. We discuss the role of factors associated with historic and continuing declines in NTD rates in most countries. These factors include the introduction and increased utilization of prenatal diagnosis, recommendations for multivitamin use in women of childbearing age, and population-wide increases in blood folate levels that have occurred since food fortification was mandated. We also discuss research needs for further NTD prevention. This is a US government work. There are no restrictions on its use. |
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Authors:
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Richard S Olney; Joseph Mulinare |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in perinatology Volume: 26 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-09-04 Completed Date: 2003-02-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 277-85 Citation Subset: IM |
Affiliation:
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National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA. rolney@cdc.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Canada / epidemiology Dietary Supplements Female Folic Acid / administration & dosage*, blood, metabolism Food, Fortified / standards Humans Infant, Newborn Neural Tube Defects / epidemiology*, prevention & control Population Surveillance Pregnancy Prenatal Diagnosis Prevalence United States / epidemiology Vitamins / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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