Document Detail

Trends in fetal and infant deaths caused by congenital anomalies.
MedLine Citation:
PMID:  12211617     Owner:  NLM     Status:  MEDLINE    
Understanding the causes that underlie the recent dramatic declines in infant deaths caused by congenital anomalies requires an appreciation of trends in cause-specific infant mortality, and especially trends in gestational age-specific and cause-specific fetal mortality. This article examines temporal changes in gestational age-specific and cause-of-death-specific fetal mortality rates in Canada, congenital anomaly-related infant mortality rates in Canada, England and Wales, and the United States, and cause-of-death-specific infant mortality rates in Canada and the United States. Fetal deaths caused by congenital anomalies at very early gestation (20-25 weeks) have increased dramatically in recent years, while fetal and infant deaths at later gestations have declined. Prenatal diagnosis and selective termination of pregnancies affected by congenital anomalies appears to be the major factor responsible for the accelerated decline in infant deaths. Further declines in overall infant mortality in industrialized countries can be expected as a result of an increasing uptake of prenatal diagnosis.
Shiliang Liu; K S Joseph; Shi Wu Wen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seminars in perinatology     Volume:  26     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2003-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  268-76     Citation Subset:  IM    
Department of Epidemiology and Community Medicine, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Canada.
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MeSH Terms
Canada / epidemiology
Congenital Abnormalities / epidemiology,  mortality*
Fetal Death / epidemiology*
Great Britain / epidemiology
Infant Mortality / trends*
Infant, Newborn
Prenatal Diagnosis / trends
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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