Document Detail

Trends in the epidemiology of IDDM during 1970-2020 in Fyn County, Denmark.
MedLine Citation:
PMID:  8842594     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To present an epidemiological model applicable to diabetes based on which prevalence rates are estimated from assumed rates of incidence and mortality of diabetes. Furthermore, this study illustrates the model by analyzing epidemiological data on IDDM in a Danish population during 1970-1990, with predictions of prevalence rates for 1990-2020. RESEARCH DESIGN AND METHODS: The epidemiological model assumes known prevalence rates as well as incidence rates and mortality at a given time. Under assumed rates of incidence and mortality of IDDM and its complications, the prevalence rate is the dependent variable, estimated as a function of calendar time. We use epidemiological data on IDDM (operationally defined as insulin-treated diabetes with onset before age 30 years), blindness, and nephropathy, as well as mortality, as reported for 1973 and 1987 in Fyn County, Denmark. RESULTS: During 1970-1990, the prevalence of IDDM increased steadily because of increasing incidence and decreasing risk of complications and mortality. The relative prevalence of patients with nephropathy increased, whereas that of blind patients decreased considerably. Under specified assumptions regarding the future levels of incidence of disease, complications, and mortality, it is estimated that the prevalence rate of IDDM in the year 2020 will be 45-60% higher than the level in the year 1990. The relative prevalence of patients with nephropathy will increase further, whereas the relative prevalence of blind patients will remain constant at a low level. CONCLUSIONS: IDDM will represent an increasing public health problem in Denmark during the next decades, with increasing overall prevalence rates and a rising proportion of patients with nephropathy. The major determinant of this trend is increasing incidence combined with declining mortality and declining risk of complications. It is strongly recommended that epidemiological models like the one presented here be further developed and implemented at regional levels to provide data for the dimensioning of the current and future diabetes care systems.
A Green; A K Sjølie; O Eshøj
Related Documents :
23081744 - Influence of tyrphostin ag490 on the expression of diabetes-associated markers in human...
23274494 - Regulation of tnfα converting enzyme activity in visceral adipose tissue of obese mice.
23056144 - Hypoglycemic activity of aqueous extracts from catharanthus roseus.
17964654 - Diabetes, hyperglycemia, and central corneal thickness: the singapore malay eye study.
17713304 - Diabetes-related lower extremity amputation rates fall significantly in south carolina.
17467104 - Current aspects on the clinical immunology and genetics of autoimmune diabetes in japan.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes care     Volume:  19     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-20     Completed Date:  1996-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  801-6     Citation Subset:  IM    
Genetic Epidemiology Research Unit, Odense University Hospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blindness / epidemiology,  mortality
Child, Preschool
Denmark / epidemiology
Diabetes Mellitus, Type 1 / epidemiology*,  mortality
Diabetic Nephropathies / epidemiology,  mortality
Diabetic Retinopathy / epidemiology,  mortality
Models, Theoretical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish populat...
Next Document:  Incidence and prevalence of diabetes in Manitoba, 1986-1991.