| Trends in chemotherapy utilization for colorectal cancer. | |
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MedLine Citation:
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PMID: 19036691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Since 1990, significant advances have occurred in the adjuvant and metastatic treatment of colorectal cancer (CRC). Not all patients may be eligible for chemotherapy (CT), and the proportions and characteristics of patients who receive treatment are not well defined. In this study, treatment patterns of patients referred to the British Columbia Cancer Agency (BCCA) with early-stage colon cancer and metastatic CRC between 1990 and 2004 are described. PATIENTS AND METHODS: This study included patients with stage II or III colon cancer or stage IV CRC at presentation referred to the BCCA during a 1-year period for 3 time cohorts: 1990, 2000, and 2004. Patients were considered treated with CT if they received > or = 1 cycle of any CT for indication of the initial referral diagnosis. RESULTS: A total of 1421 patients were included: stage II/III, n = 915; stage IV, n = 506. Chemotherapy utilization increased significantly from 1990 to 2004 for adjuvant CT (1990: 29%; 2000: 45%; 2004: 52%; P < .001) and for palliative CT (1990: 35%; 2000: 51%; 2004: 63%; P < .001). The proportion of patients with stage II disease treated with adjuvant CT dramatically increased (1990: 4%; 2000: 26%; 2004: 30%; P < .001). The use of palliative CT was significantly associated with male sex (P = .025). Among older patients, only 25% received adjuvant CT, and 31% received palliative CT. CONCLUSION: In this population-based study, adjuvant and palliative CT utilization increased significantly between 1990 and 2004. The majority of patients aged > 70 years did not receive CT, and women appeared less likely to receive palliative CT. Such disparities in CT utilization require further investigation. |
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Authors:
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Daniel Renouf; Hagen Kennecke; Sharlene Gill |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical colorectal cancer Volume: 7 ISSN: 1533-0028 ISO Abbreviation: Clin Colorectal Cancer Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-27 Completed Date: 2009-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120693 Medline TA: Clin Colorectal Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 386-9 Citation Subset: IM |
Affiliation:
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British Columbia Cancer Agency, Vancouver, Canada. drenouf@bccaner.bc.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Agents / therapeutic use* British Columbia / epidemiology Chemotherapy, Adjuvant Chi-Square Distribution Colorectal Neoplasms / drug therapy*, epidemiology, pathology Female Humans Male Middle Aged Neoplasm Metastasis Neoplasm Staging Palliative Care Retrospective Studies Risk Factors Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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