| Trends in characteristics of surgically treated early gastric cancer patients after the introduction of gastric cancer treatment guidelines in Japan. | |
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MedLine Citation:
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PMID: 20602192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The gastric cancer treatment guidelines (Guidelines) of the Japanese Gastric Cancer Association allow endoscopic treatment and a modified gastrectomy for the treatment of early gastric cancer (EGC). Endoscopic treatment is indicated for EGC with a minimal chance of nodal metastasis. Consequently, surgeons will likely treat an increasing number of EGC patients with greater chance of nodal metastasis using a reduced extent of lymphadenectomy. The aim of this study was to investigate the trends in characteristics and long-term oncological outcomes of surgically treated EGC patients after the introduction of the Guidelines. METHODS: Between 2001 and 2003, 696 patients underwent a gastrectomy according to the Guidelines. These 696 patients (the Guidelines group) were retrospectively compared with 635 patients (the control group) who had undergone a gastrectomy between 1991 and 1995 (before the introduction of the Guidelines). RESULTS: The incidence of nodal metastasis in mucosal cancers was higher in the Guidelines group than in the control group (6.5% vs 2.6%). The proportion of D2 or greater extended lymphadenectomy in the Guidelines group was lower than that in the control group (29.7% vs 62.5%). Nevertheless, the 5-year survival rate in the Guidelines group was similar to that in the control group (94.2% vs 92.3%). CONCLUSION: Surgeons treated more cases of mucosal cancer with nodal metastasis after the introduction of the Guidelines. The long-term oncological outcomes for patients with EGC remained excellent. So far, the Guidelines for the treatment of EGC appear acceptable. |
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Authors:
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Norimitsu Tanaka; Hitoshi Katai; Hirokazu Taniguchi; Makoto Saka; Shinji Morita; Takeo Fukagawa; Takuji Gotoda |
Publication Detail:
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Type: Journal Article Date: 2010-07-03 |
Journal Detail:
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Title: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Volume: 13 ISSN: 1436-3291 ISO Abbreviation: Gastric Cancer Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886238 Medline TA: Gastric Cancer Country: Japan |
Other Details:
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Languages: eng Pagination: 74-7 Citation Subset: IM |
Affiliation:
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Gastric Surgery Division, National Cancer Center Hospital, Chuo-ku, Tokyo, 104-0045, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Follow-Up Studies Gastrectomy / methods* Gastric Mucosa / pathology Gastroscopy / methods* Humans Japan Lymphatic Metastasis Male Middle Aged Practice Guidelines as Topic* Retrospective Studies Stomach Neoplasms / pathology, surgery* Survival Rate Time Factors Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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