Document Detail


Trends in bronchiectasis mortality in England and Wales.
MedLine Citation:
PMID:  20303725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To provide information on the burden of bronchiectasis in England and Wales, we have examined trends in mortality using death certificate data available from the Office of National Statistics.
METHODS: We extracted data on deaths due to non-cystic fibrosis bronchiectasis for 2001-2007 inclusive and stratified deaths by sex and age group. We used Poisson regression to compare mortality rates.
RESULTS: Between 2001 and 2007, 5745 bronchiectasis related deaths were registered in England and Wales. When standardized to the 2007 population, this showed a rise in absolute numbers from 797 (2001) to 908 (2007). Statistical analyses suggested that the mortality rate is currently increasing at 3%/year (p < 0.001). Mortality rates were similar between men and women but there was a strong statistical interaction between age group and year (p < 0.001) Rates were increasing in the two oldest age groups but falling in the three youngest groups.
DISCUSSION: Currently just under 1000 people die from bronchiectasis each year in England and Wales. We found the number of deaths to be increasing at 3% per year. Although overall mortality was increasing, rates were increasing in older groups but falling in the younger groups. These mortality rates may underestimate the burden of disease from bronchiectasis as lack of knowledge about the disease may lead to underreporting. These are also mortality rather than incidence data and may reflect improvements in treatment. Bronchiectasis therefore remains a significant concern. Clinical provision will potentially need to increase in order to care for this patient group.
Authors:
Helen J Roberts; Richard Hubbard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-19
Journal Detail:
Title:  Respiratory medicine     Volume:  104     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  981-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Nottingham University Hospitals NHS Trust, United Kingdom. helen.roberts3@nuh.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Bronchiectasis / epidemiology,  mortality*
Child
Child, Preschool
Death Certificates
England / epidemiology
Female
Humans
Infant
Male
Middle Aged
Poisson Distribution
Prevalence
Survival Rate / trends
Wales / epidemiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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