| Trends in biomedical engineering: focus on Regenerative Medicine. | |
| | |
MedLine Citation:
|
PMID: 22065385 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract?Regenerative medicine is a critical frontier in biomedical and clinical research. The major progresses in the last few years were driven by a strong clinical need which could benefit from regenerative medicine outcomes for the treatment of a large number of conditions including birth defects, degenerative and neoplastic diseases, and traumatic injuries. Regenerative medicine applies the principles of engineering and life sciences to enhance the comprehension of the fundamental biological mechanisms underlying the structure-function relationships in physiologic and pathologic tissues and to accomplish alternative strategies for developing in vitro biological substitutes which are able to restore, maintain, or improve tissue, and organ function. This paper reviews selected approaches currently being investigated at Politecnico di Milano in the field of regenerative medicine. Specific tissue-oriented topics are divided in three sections according to each developmental stage: in vitro study, pre-clinical study, and clinical application. In vitro studies investigate the basic phenomena related to gene delivery, stem cell behavior, tissue regeneration, and to explore dynamic culture potentiality in different applications: cardiac and skeletal muscle, cartilage, hematopoietic system, peripheral nerve, and gene delivery. Specific fields of regenerative medicine, i.e., bone, blood vessels, and ligaments engineering have already reached the preclinical stage providing promising insights for further research towards clinical applications. The translation of the results obtained during in vitro and preclinical steps into clinical organ replacement is a very challenging issue, which can offer a valid alternative to fight morbidity, organ shortage, and ethical-social problems associated with allotransplantation as shown in the clinical case reported in this review. |
| | |
Authors:
|
M Adelaide Asnaghi; Gabriele Candiani; Silvia Farè; Gianfranco B Fiore; Paola Petrini; Manuela T Raimondi; Monica Soncini; Sara Mantero |
Related Documents
:
|
22542265 - Development, content validity, and piloting of an instrument designed to measure manage... 21390575 - Metaphysical and value underpinnings of traditional medicine in west africa. 18406385 - Emergency care and managing toxicoses in the exotic animal patient. 7789105 - Tatian's 'rejection' of medicine in the second century. 9883105 - Rural proceduralists: an endangered species. report of the queensland rural indemnity s... 17532045 - Current status of coastal zone issues and management in china: a review. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of applied biomaterials & biomechanics : JABB Volume: 9 ISSN: 1722-6899 ISO Abbreviation: J Appl Biomater Biomech Publication Date: 2011 May-Aug |
Date Detail:
|
Created Date: 2011-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101180437 Medline TA: J Appl Biomater Biomech Country: Italy |
Other Details:
|
Languages: eng Pagination: 73-86 Citation Subset: IM |
Affiliation:
|
Department of Bioengineering, Politecnico di Milano, Milano - Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microarray-based identification of aminopeptidase N/CD13 target genes in keratinocyte conditioned me...
Next Document: Trends in biomedical engineering: focus on Smart Bio-Materials and Drug Delivery.