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Trends in Incidence, Therapy and Outcome of Localized Nodal and Extranodal Marginal Zone Lymphomas; Declining Incidence and Inferior Outcome for Gastro-Intestinal Sites.
MedLine Citation:
PMID:  23302044     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Population-based series analyzing clinical implications of nodal versus extranodal presentation of marginal zone lymphoma(MZL) are lacking. We studied clinical differences and trends in incidence, therapy and survival of nodal and extranodal MZL, and of MZL at different extranodal sites, in a population-based cohort. All patients with localized (AAS I&II) nodal (n=211), splenic (n=54) and extranodal (n=1449) MZL, diagnosed between 1994-2010, were selected from The Netherlands Cancer Registry. Between 1994 and 2010 the incidence of nodal and extranodal MZL increased. The incidence of gastric MZL decreased. Patients with nodal MZL received more chemotherapy and targeted therapies than their extranodal counterparts. A trend in time towards less chemotherapy and more irradiation was observed. Overall survival (OS) curves for nodal and extranodal MZL overlapped (5-year OS 76% and 77%, respectively). Patients with a primary gastro-intestinal(GI) localization had inferior OS compared to patients with non-GI extranodal MZL (5-year OS 71% and 85%,p<0.0001). Patients with localized extranodal MZL presented more commonly with stage I disease, but their clinical presentation and survival was otherwise similar to patients with localized nodal MZL. MZL arising in the GI tract have not a good prognosis and require a different treatment approach.
Authors:
Marion J J Kuper-Hommel; Saskia A M van de Schans; Gerard Vreugdenhil; J Han J M van Krieken; Jan Willem W Coebergh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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