Document Detail

Trends and disease burden of enteric fever in Guangxi province, China, 1994-2004.
MedLine Citation:
PMID:  20865074     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the burden of enteric fever through trends in morbidity and mortality, bacterial species and antimicrobial resistance in Guangxi, a southern, subtropical, coastal province of China with a disproportionally large burden of enteric fever.
METHODS: Data on morbidity and mortality caused by enteric fever between 1994 and 2004 were extracted from the Guangxi Center for Disease Control and Prevention. Laboratory-based surveillance and outbreak investigations were integrated with reports of notifiable infectious diseases to estimate the bacterial species-specific incidence of enteric fever. To adjust for underreporting, survey data were collected from three prefectures that represent the hyper-, moderate- and low-endemic regions of Guangxi province.
FINDINGS: In Guangxi province, enteric fever incidence rate varied over the study period, with a peak of 13.5 cases per 100 000 population in 1995 and a low of 6.5 in 2003. The disease occurred most frequently during the summer and autumn months and in the group aged 10-49 years. The incidence of enteric fever varied by region within Guangxi province. During the 11-year period covered by the study, 61 outbreaks of enteric fever were reported, and Salmonella paratyphi A (SPA) became the predominant causative agent in the province.
CONCLUSION: Prospective studies may provide a better understanding of the reason for the shifting epidemiology of enteric fever in Guangxi province. Given the emergence of resistance to first- and second-line antimicrobials for the treatment of enteric fever, a bivalent vaccine against both SPA and S. typhi would facilitate for disease control.
Bai-Qing Dong; Jin Yang; Xuan-Yi Wang; Jian Gong; Lorenz von Seidlein; Ming-Liu Wang; Mei Lin; He-Zhuang Liao; R Leon Ochiai; Zhi-Yi Xu; Luis Jodar; John D Clemens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-07
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  88     ISSN:  1564-0604     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-06     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  689-96     Citation Subset:  IM    
Guangxi Center for Disease Control and Prevention, Nanning, China.
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MeSH Terms
Age Distribution
China / epidemiology
Disease Outbreaks
Drug Resistance, Bacterial
Middle Aged
Sex Distribution
Typhoid Fever / epidemiology*,  mortality

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