Document Detail

Trends and antibiotic susceptibility patterns of methicillin-resistant and methicillin-sensitive Staphylococcus aureus in an outpatient dermatology facility.
MedLine Citation:
PMID:  23325388     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether the relative proportions of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S aureus (MSSA) were changing or stable in an outpatient dermatology clinic and to examine the antibiotic susceptibility profiles of S aureus isolates.
DESIGN: Retrospective observational data were collected from skin culture isolates annually between January 1, 2005, and December 31, 2010, and monthly during the 6-month period of January 1, 2011, to June 30, 2011.
SETTING: The University of Miami Hospital outpatient dermatology clinic.
PARTICIPANTS: A total of 387 S aureus isolates were analyzed between January 1, 2005, and June 30, 2011, from adult and pediatric patients.
MAIN OUTCOME MEASURES: The relative proportions of MRSA and MSSA skin culture isolates were measured, along with antibiotic sensitivity profiles.
RESULTS: The overall relative proportion of MRSA was 35.7%. The overall relative proportion of MSSA was 64.3%. During the last 6 months of the study, the relative proportion of MRSA was 33.3%, while the relative proportion of MSSA was 66.7%. The relative proportion of MRSA from January 1, 2008, through December 31, 2010, was significantly higher than the relative proportion from January 1, 2005, through December 31, 2007 (45.3% vs 28.3%, P = .001). MRSA became more sensitive to ciprofloxacin, while MSSA became more resistant to ciprofloxacin, clindamycin, gentamicin sulfate, and trimethoprim-sulfamethoxazole.
CONCLUSIONS: The relative proportion of MRSA in the S aureus isolates increased by 17.0% during the last 3 years of our study. Despite this increase, MRSA became more sensitive to ciprofloxacin, while MSSA demonstrated increased antibiotic resistance to ciprofloxacin, clindamycin, gentamicin, and trimethoprim-sulfamethoxazole.
Marilyn Zabielinski; Michael P McLeod; Cheryl Aber; Jan Izakovic; Lawrence A Schachner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JAMA dermatology     Volume:  149     ISSN:  2168-6084     ISO Abbreviation:  JAMA Dermatol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-06-11     Completed Date:  2013-07-30     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101589530     Medline TA:  JAMA Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  AIM; IM    
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MeSH Terms
Ambulatory Care Facilities / trends*
Colony Count, Microbial
Disease Susceptibility / epidemiology*
Florida / epidemiology
Follow-Up Studies
Methicillin-Resistant Staphylococcus aureus / isolation & purification*
Microbial Sensitivity Tests
Outpatients / statistics & numerical data*
Retrospective Studies
Staphylococcal Infections / drug therapy,  epidemiology*,  microbiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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