| Tremor, ataxia and dementia in older men may indicate a carrier of the fragile X syndrome. | |
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MedLine Citation:
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PMID: 12791039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently it has been reported that late-onset tremor, gait unsteadiness and dementia can be associated with brain atrophy in males of normal intelligence and the pre-mutation carrier state of the fragile X syndrome. We have shown, by means of a telephone survey, that this association is probably causal rather than coincidental. These findings have uncovered another testable cause of late-onset neurological symptoms in males, which also has serious genetic implications for their daughters who are at risk of having sons with full mutations causing mental handicap - the fragile X syndrome. |
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Authors:
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C Rogers; M W Partington; G M Turner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical genetics Volume: 64 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-06 Completed Date: 2004-02-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: Denmark |
Other Details:
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Languages: eng Pagination: 54-6 Citation Subset: IM |
Affiliation:
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Hunter Genetics, The Hunter Area Health Service, Waratah, New South Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Ataxia / genetics* Dementia / genetics* Fragile X Syndrome / genetics* Heterozygote Humans Male Middle Aged Tremor / genetics* |
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