Document Detail


Trehalose production: exploiting novel approaches.
MedLine Citation:
PMID:  12220904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trehalose (alpha-D-glucopyranosyl alpha-D-glucopyranoside) is a unique sugar capable of protecting biomolecules against environmental stress. It is a stable, colorless, odor-free and non-reducing disaccharide, and is widespread in nature. Trehalose has a key role in the survival of some plants and insects, termed anhydrobionts, in harsh environments, even when most of their water body is removed. The properties of these types of organisms drove attention towards the study of trehalose. Since then, it proved to be an active stabilizer of enzymes, proteins, biomasses, pharmaceutical preparations and even organs for transplantation. Recently, trehalose has been accepted as a safe food ingredient by the European regulation system following approval by the US Food and Drug Administration. The wide range of applications of this sugar has increased the interest of many research groups into the development of novel and economically feasible production systems. This article provides a comprehensive review of the current achievements in the biotechnological production of trehalose.
Authors:
Chiara Schiraldi; Isabella Di Lernia; Mario De Rosa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in biotechnology     Volume:  20     ISSN:  0167-7799     ISO Abbreviation:  Trends Biotechnol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2003-04-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8310903     Medline TA:  Trends Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  IM    
Affiliation:
Section of Biotechnology and Molecular Biology, Department of Experimental Medicine, Second University of Naples, via De Crecchio 7, 80138, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Archaea / metabolism*
Bacteria / metabolism*
Fungi / metabolism*
Microbiology / trends
Plants / metabolism
Quality Control
Species Specificity
Starch / metabolism
Trehalose / biosynthesis*,  economics,  isolation & purification*
Chemical
Reg. No./Substance:
9005-25-8/Starch; 99-20-7/Trehalose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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