| Regulatory T cells play a role in T-cell receptor CDR2 peptide regulation of experimental autoimmune encephalomyelitis. | |
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MedLine Citation:
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PMID: 22044096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eliciting T-cell receptor (TCR) -specific responsiveness has been known to provide an effective autoregulatory mechanism for limiting inflammation mediated by T effector cells. Our previous use of TCR peptides derived from the CDR3 regions of a pathogenic TCR effectively reversed ongoing experimental autoimmune encephalomyelitis (EAE) in a humanized TCR transgenic model. In this study, we use the TCR BV8S2 CDR2 peptide in the non-transgenic C57BL/6 EAE model to down-regulate the heterogeneous TCR BV8S2(+) MOG-35-55-specific pathogenic T-cell population and demonstrate successful treatment of EAE after disease onset. Suppression of disease was associated with reduced MOG-35-55-specific and non-specific T-cell production of interleukin-17a and interferon-γ in the central nervous system, as well as reduced numbers of CD4(+) and Foxp3(+) T cells in the central nervous system. With the use of Foxp3-GFP and Foxp3 conditional knockout mice, we demonstrate that the TCR CDR2 peptide treatment effect is dependent on the presence of Foxp3(+) regulatory T cells and that regulatory T cell numbers are significantly expanded in the periphery of treated mice. Hence, TCR CDR2 peptide therapy is effective in regulating heterogeneous, pathogenic T-cell populations through the activity of the Foxp3(+) regulatory T cell population. |
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Authors:
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Abigail C Buenafe; Shayne Andrew; Halina Offner; Arthur A Vandenbark |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Immunology Volume: 135 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-12 Completed Date: 2012-03-30 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 168-79 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Immunology © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Neuroimmunology Research, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA. buenafea@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental / drug therapy, immunology* Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Antigen, T-Cell, alpha-beta / immunology*, therapeutic use T-Lymphocytes, Regulatory / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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NS23221/NS/NINDS NIH HHS; R01 NS023221-22/NS/NINDS NIH HHS; R01 NS023221-23/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, T-Cell, alpha-beta |
| Comments/Corrections | |
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