Document Detail


Treg cells in rheumatoid arthritis: an update.
MedLine Citation:
PMID:  23888361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses to autoantigens. Regulatory CD4(+) T-cells (Tregs) underpin one of the key mechanisms of self-tolerance and are a major focus of study in RA and other autoimmune diseases. In order to design new and improved therapies to reinstate self-tolerance, and perhaps cure disease, we need to understand the complex mechanism of action of Tregs. This review addresses recent findings in the field of Tregs in RA, with particular focus on identification of potential defects in Treg-mediated self-tolerance mechanisms present in RA patients, as well as how Tregs interact with other cells in the inflamed joints. As antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, we also discuss new strategies currently being investigated which expand or induce de novo generation of Tregs.
Authors:
Faye A H Cooles; John D Isaacs; Amy E Anderson
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  15     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-26     Completed Date:  2014-03-13     Revised Date:  2014-05-27    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antirheumatic Agents / pharmacology,  therapeutic use
Arthritis, Rheumatoid / drug therapy,  immunology*
Cell Communication / immunology
Dendritic Cells / immunology
Humans
Monocytes / immunology
Osteoclasts / immunology
Self Tolerance / drug effects,  immunology
Synovial Membrane / immunology
T-Lymphocyte Subsets / immunology
T-Lymphocytes, Regulatory / drug effects,  immunology*
Grant Support
ID/Acronym/Agency:
18155//Arthritis Research UK
Chemical
Reg. No./Substance:
0/Antirheumatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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