| Trefoil factor family domain peptides. | |
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MedLine Citation:
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PMID: 9463569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Within the past 15 years a new family of peptides has been identified, known as trefoil factor family (TFF) domain peptides; they are associated with mucin-secreting epithelial cells and synthesised predominantly in the gastrointestinal tract. They share a highly conserved physical structure, and their role in mucosal defence and healing is becoming increasingly clear, more recently a tumour suppressor function has been postulated. Outside the gastrointestinal tract, members of this group of peptides have also been identified in the normal hypothalamus and pituitary, and in normal breast tissue where it is responsive to oestrogen stimulation. Evidence of peptide expression has been found in a range of urological, gynaecological, gastrointestinal, pulmonary and breast carcinomas, and in the last two it appears to carry prognostic significance. The present review aims to summarise the rapidly expanding data on the role of these peptides in epithelial inflammation, repair and neoplasia. |
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Authors:
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G R Williams; N A Wright |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 431 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-17 Completed Date: 1998-02-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 299-304 Citation Subset: IM |
Affiliation:
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ICRF Histopathology Unit, Lincoln's Inn Fields, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Digestive System / metabolism Growth Substances / physiology* Humans Immunity, Mucosal / physiology Mucins* Muscle Proteins* Neoplasms / metabolism Neuropeptides* Peptides / physiology* Tissue Distribution Tumor Markers, Biological Wound Healing / physiology |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 0/Mucins; 0/Muscle Proteins; 0/Neuropeptides; 0/Peptides; 0/TFF3 protein, rat; 0/Tumor Markers, Biological; 146046-78-8/trefoil factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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