Document Detail

Trefoil factor family domain peptides.
MedLine Citation:
PMID:  9463569     Owner:  NLM     Status:  MEDLINE    
Within the past 15 years a new family of peptides has been identified, known as trefoil factor family (TFF) domain peptides; they are associated with mucin-secreting epithelial cells and synthesised predominantly in the gastrointestinal tract. They share a highly conserved physical structure, and their role in mucosal defence and healing is becoming increasingly clear, more recently a tumour suppressor function has been postulated. Outside the gastrointestinal tract, members of this group of peptides have also been identified in the normal hypothalamus and pituitary, and in normal breast tissue where it is responsive to oestrogen stimulation. Evidence of peptide expression has been found in a range of urological, gynaecological, gastrointestinal, pulmonary and breast carcinomas, and in the last two it appears to carry prognostic significance. The present review aims to summarise the rapidly expanding data on the role of these peptides in epithelial inflammation, repair and neoplasia.
G R Williams; N A Wright
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  431     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-17     Completed Date:  1998-02-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
ICRF Histopathology Unit, Lincoln's Inn Fields, London, UK.
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MeSH Terms
Digestive System / metabolism
Growth Substances / physiology*
Immunity, Mucosal / physiology
Muscle Proteins*
Neoplasms / metabolism
Peptides / physiology*
Tissue Distribution
Tumor Markers, Biological
Wound Healing / physiology
Reg. No./Substance:
0/Growth Substances; 0/Mucins; 0/Muscle Proteins; 0/Neuropeptides; 0/Peptides; 0/TFF3 protein, rat; 0/Tumor Markers, Biological; 146046-78-8/trefoil factor

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