Document Detail


Trefoil factor family domain peptides.
MedLine Citation:
PMID:  9463569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within the past 15 years a new family of peptides has been identified, known as trefoil factor family (TFF) domain peptides; they are associated with mucin-secreting epithelial cells and synthesised predominantly in the gastrointestinal tract. They share a highly conserved physical structure, and their role in mucosal defence and healing is becoming increasingly clear, more recently a tumour suppressor function has been postulated. Outside the gastrointestinal tract, members of this group of peptides have also been identified in the normal hypothalamus and pituitary, and in normal breast tissue where it is responsive to oestrogen stimulation. Evidence of peptide expression has been found in a range of urological, gynaecological, gastrointestinal, pulmonary and breast carcinomas, and in the last two it appears to carry prognostic significance. The present review aims to summarise the rapidly expanding data on the role of these peptides in epithelial inflammation, repair and neoplasia.
Authors:
G R Williams; N A Wright
Related Documents :
23774839 - Tracking the interplay between bound peptide and the lid domain of dnak, using molecula...
6548019 - Phi--a new brain-gut peptide.
22947219 - Solution nmr structure and molecular dynamics simulations of murine 18.5-kda myelin bas...
6106619 - Immunoreactive somatostatin and vasoactive intestinal peptide in the digestive tract of...
3028489 - Chemical modification of guanidinium groups of vasoactive intestinal peptide.
22982599 - Stability and membrane interactions of an autotransport protein: md simulations of the ...
10933779 - The effects of polar and/or ionizable residues in the core and flanking regions of hydr...
19039369 - Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applica...
9878809 - The ktr and mnn1 mannosyltransferase families of saccharomyces cerevisiae.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  431     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-17     Completed Date:  1998-02-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Affiliation:
ICRF Histopathology Unit, Lincoln's Inn Fields, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Digestive System / metabolism
Growth Substances / physiology*
Humans
Immunity, Mucosal / physiology
Mucins*
Muscle Proteins*
Neoplasms / metabolism
Neuropeptides*
Peptides / physiology*
Tissue Distribution
Tumor Markers, Biological
Wound Healing / physiology
Chemical
Reg. No./Substance:
0/Growth Substances; 0/Mucins; 0/Muscle Proteins; 0/Neuropeptides; 0/Peptides; 0/TFF3 protein, rat; 0/Tumor Markers, Biological; 146046-78-8/trefoil factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cytotoxicity of fractionated paclitaxel (Taxol) administration in vitro.
Next Document:  Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene express...