Document Detail

Trefoil Factors in Saliva and Gingival Tissues of Patients With Chronic Periodontitis.
MedLine Citation:
PMID:  22181686     Owner:  NLM     Status:  Publisher    
Background: Trefoil factors (TFFs) are secreted molecules which are involved in cytoprotection against tissue damage, and the immune response. TFFs have been detected in saliva and oral tissues, but their clinical significance has never been investigated in patients with chronic periodontitis. The objective of our study was to determine if TFF expression in saliva and gingival tissues was associated with periodontal pathology. Methods: Saliva and gingival tissue samples were collected from 25 non-periodontitis subjects, and 25 chronic periodontitis patients. Enzyme-Linked Immunosorbent Assay (ELISA) and immunohistochemical methods were used to evaluate the expression of TFFs (TFF1, TFF2, and TFF3) in saliva and gingival tissues, respectively. Periodontopathic bacteria were quantified by real-time polymerase chain reaction. Results: Reduced salivary TFF1 and TFF3 concentrations were observed in chronic periodontitis patients (p = 0.003 and p < 0.001, respectively). Decreased TFF3 expression in gingival tissues of chronic periodontitis patients was demonstrated (p = 0.041). Levels of salivary TFF3 concentrations were negatively correlated with periodontal pathology and number of Porphyromonas gingivalis and Tannerella forsythensis. Conclusions: Altered expression of TFFs in saliva and gingival tissues was detected in chronic periodontitis patients. The results suggest that TFF3 may involve in the pathogenesis of periodontal disease.
Ponlatham Chaiyarit; Anek Chayasadom; Nawarat Wara-Aswapati; Doodsadee Hormdee; Sapatporn Sittisomwong; Sirinun Nakaresisoon; Mie Hessellund Samson; Waranuch Pitiphat; Andrew S Giraud
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-19
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand.
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