| Treatment options for paediatric diabetes. | |
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MedLine Citation:
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PMID: 20666700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IMPORTANCE OF THE FIELD: Diabetes mellitus is the most common endocrine disease in childhood. The global incidence of diabetes emphasizes the health, social and financial magnitude of this disease and the importance of optimizing disease management and prevention. AREAS COVERED IN THIS REVIEW: This article reviews the treatments options for type 1 and 2 diabetes in children, focusing on insulin regimens and new alternative therapies. WHAT THE READER WILL GAIN: The treatment goals for children with diabetes mellitus are to achieve normal development with prevention of complications. Insulin is the primary medication in the treatment of type 1 diabetes. New therapeutic options and prevention strategies (cellular therapies, immunomodulation and vaccination) aim to preserve residual beta-cell function. There are limited data about the effectiveness and safety of treatment strategies for type 2 diabetes. Many oral agents are approved only for use in adults and have not been yet studied in children. TAKE-HOME MESSAGE: Therapy regimens should be adapted to the lifestyle of individual patients to achieve optimal blood glucose control. The replacement of beta-cells, preservation of the residual beta-cell function and investigation of additional oral treatment options, present a hope for a cure. |
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Authors:
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Alberto Verrotti; Rosa Maria Chiuri; Annalisa Blasetti; Angelika Mohn; Francesco Chiarelli |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 11 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2011-08-11 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 2483-95 Citation Subset: IM |
Affiliation:
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University of Chieti, Department of Pediatrics, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Blood Glucose / drug effects, genetics, metabolism Child Diabetes Mellitus, Type 1 / blood, genetics, therapy* Diabetes Mellitus, Type 2 / blood, genetics, therapy* Gene Therapy / trends* Humans Hypoglycemic Agents / pharmacology, therapeutic use* Insulin / therapeutic use Islets of Langerhans Transplantation / trends* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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