| Treatment with tianeptine induces antidepressive-like effects and alters the neurotrophin levels, mitochondrial respiratory chain and cycle Krebs enzymes in the brain of maternally deprived adult rats. | |
| | |
MedLine Citation:
|
PMID: 23325329 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Maternally deprived rats were treated with tianeptine (15 mg/kg) once a day for 14 days during their adult phase. Their behavior was then assessed using the forced swimming and open field tests. The BDNF, NGF and energy metabolism were assessed in the rat brain. Deprived rats increased the immobility time, but tianeptine reversed this effect and increased the swimming time; the BDNF levels were decreased in the amygdala of the deprived rats treated with saline and the BDNF levels were decreased in the nucleus accumbens within all groups; the NGF was found to have decreased in the hippocampus, amygdala and nucleus accumbens of the deprived rats; citrate synthase was increased in the hippocampus of non-deprived rats treated with tianeptine and the creatine kinase was decreased in the hippocampus and amygdala of the deprived rats; the mitochondrial complex I and II-III were inhibited, and tianeptine increased the mitochondrial complex II and IV in the hippocampus of the non-deprived rats; the succinate dehydrogenase was increased in the hippocampus of non-deprived rats treated with tianeptine. So, tianeptine showed antidepressant effects conducted on maternally deprived rats, and this can be attributed to its action on the neurochemical pathways related to depression. |
| | |
Authors:
|
Franciela P Della; Helena M Abelaira; Gislaine Z Réus; Maria Augusta B Dos Santos; Débora B Tomaz; Altamir R Antunes; Giselli Scaini; Meline O S Morais; Emilio L Streck; João Quevedo |
Related Documents
:
|
6646809 - The pathology induced in laboratory rats by metacestodes of taenia crassiceps and mesoc... 11023709 - Development of a physiologically based pharmacokinetic model of organic solvent in rats. 22963239 - Transforming growth factor beta induces sensory neuronal hyperexcitability, and contrib... 9524209 - Quantitation of age-related mitochondrial dna deletions in rat tissues shows that their... 14207059 - Proliferative activity of the lymphatic tissues of rats as studied with tritium-labeled... 2241559 - Does survival depend on the amount of autotransplanted splenic tissue? 10492619 - Electroencephalographic study of the effect of neurotoxin dsp-4 in iron model of chroni... 11092529 - Immunomorphometric studies of proteinuria in individual deep and superficial nephrons o... 10404949 - Biomechanical properties and chemical composition of the aorta in genetic hypertensive ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-18 |
Journal Detail:
|
Title: Metabolic brain disease Volume: - ISSN: 1573-7365 ISO Abbreviation: Metab Brain Dis Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Laboratório de Neurociências, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), and Núcleo de Excelência em Neurociências Aplicadas de Santa Catarina (NENASC), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus.
Next Document: The Hygiene Theory Harnessing Helminths and Their Ova to Treat Autoimmunity.