Document Detail

Treatment with teriparatide in a patient with pregnancy-associated osteoporosis.
MedLine Citation:
PMID:  20230328     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The decrease of BMD during a physiological pregnancy can in rare cases be intensified and lead to dramatic microarchitectural changes, which causes an increase incidence of fractures, preferably at the spine. This dramatic clinical picture is called pregnancy-associated osteoporosis.
CASE HISTORY: We present the case of a 40-year-old woman (gravida IV, para II) with acute back pain right after delivery due to four fractures of the spine. The diagnosis was confirmed by dual-energy X-ray absorptiometry measurement result (T-score -4.1 SD (0.598 g/cm(2)) at the lumbar spine (L1-L4), T-score -1.5 SD (0.759 g/cm(2)) at the total hip). Due to the severity of symptoms, a therapy with teriparatide (20 mg daily) was started for a period of 18 months.
RESULTS: After end of therapy, the T-score had significantly increased at the lumbar spine as well as at the hip (T-score of -2.1 (0.813 g/cm(2)) and -0.6 (0.864 g/cm(2)), respectively. The relative increase of BMD at the spine and total hip was 36% and 13.8%, respectively.
DISCUSSION: Our report demonstrates the successful use of teriparatide underlined by the increase of bone mineral density and the improvement of clinical symptoms in a case of severe pregnancy-associated osteoporosis for the first time.
Lars Hellmeyer; Jelena Boekhoff; Peyman Hadji
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  725-8     Citation Subset:  IM    
Department of Obstetrics and Perinatal Medicine, Philipps University Marburg, Marburg, Germany.
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MeSH Terms
Bone Density
Bone Density Conservation Agents / therapeutic use*
Osteoporosis / drug therapy*,  etiology
Pregnancy Complications / drug therapy*
Teriparatide / therapeutic use*
Reg. No./Substance:
0/Bone Density Conservation Agents; 52232-67-4/Teriparatide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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