Document Detail

Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial.
MedLine Citation:
PMID:  16297506     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Nutrients putatively implicated in pressure ulcer healing were evaluated in a clinical setting. METHODS: Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine (9 g), vitamin C (500 mg) and zinc (30 mg). Nutritional status measurements (dietary, anthropometric and biochemical) and pressure ulcer size and severity (by PUSH tool; Pressure Ulcer Scale for Healing; 0=completely healed, 17=greatest severity) were measured weekly for 3 weeks. RESULTS: Patients' age and BMI ranges were 37-92 years and 16.4-28.1 k g/m2) respectively. Baseline PUSH scores were similar between groups (8.7+/-0.5). Only patients receiving additional arginine, vitamin C and zinc demonstrated a clinically significant improvement in pressure ulcer healing (9.4+/-1.2 vs. 2.6+/-0.6; baseline and week 3, respectively; P<0.01). All patient groups presented with low serum albumin and zinc and elevated C-reactive protein. There were no significant changes in biochemical markers, oral dietary intake or weight in any group. CONCLUSIONS: In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer healing. The results need to be confirmed in a larger study.
Katherine J Desneves; Bree E Todorovic; Ann Cassar; Timothy C Crowe
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-11-15
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  24     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  979-87     Citation Subset:  IM    
Department of Nutrition and Dietetics, Austin Health, Studley Road, Heidelberg 3084, and School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia.
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MeSH Terms
Aged, 80 and over
Antioxidants / therapeutic use
Arginine / therapeutic use*
Ascorbic Acid / therapeutic use*
Blood Chemical Analysis
Dietary Supplements
Middle Aged
Nutritional Status
Pressure Ulcer / drug therapy*
Severity of Illness Index
Trace Elements / therapeutic use
Treatment Outcome
Wound Healing / drug effects*
Zinc / therapeutic use*
Reg. No./Substance:
0/Antioxidants; 0/Trace Elements; 50-81-7/Ascorbic Acid; 74-79-3/Arginine; 7440-66-6/Zinc

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