| Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate increases intestinal carnitine absorption in rats. | |
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MedLine Citation:
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PMID: 18620058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation of PPARalpha by clofibrate has recently been shown to cause upregulation of the high-affinity carnitine transporter novel organic cation transporter (OCTN) 2 in small intestine. This strongly suggests that PPARalpha activation in response to clofibrate treatment improves the absorption of carnitine from the diet. To test this hypothesis, we performed an experiment with rats which were fed diets with or without 5 g clofibrate/kg diet and with or without 5 g L-carnitine/kg diet. PPARalpha was significantly activated by clofibrate in small intestine as evidenced by increased relative mRNA concentrations of the PPARalpha target gene acyl-CoA oxidase (P < 0.05). Relative mRNA concentration of OCTN2 in small intestine was significantly increased by clofibrate (P < 0.05) but not the carnitine supplementation, whereas relative mRNA concentrations of other carnitine transporters (OCTN1, ATB(0+)) in small intestine were not influenced by either clofibrate or carnitine. The absorption rate of carnitine in small intestine was markedly higher in rats treated with clofibrate than in those treated without clofibrate (P < 0.05). In conclusion, the present study shows that administration of clofibrate to rats increases carnitine absorption in small intestine which is probably due to the observed upregulation of OCTN2 mediated by activation of PPARalpha. |
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Authors:
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Robert Ringseis; Silvia Lüdi; Frank Hirche; Klaus Eder |
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Publication Detail:
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Type: Journal Article Date: 2008-06-22 |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 58 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
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Languages: eng Pagination: 58-64 Citation Subset: IM |
Affiliation:
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Institut für Agrar- und Ernährungswissenschaften, Martin-Luther-Universität Halle-Wittenberg, Emil-Abderhalden-Strasse 26, D-06108 Halle (Saale), Germany. robert.ringseis@landw.uni-halle.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Transport Systems
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biosynthesis Animals Antilipemic Agents / pharmacology* Carnitine / metabolism* Carrier Proteins / biosynthesis Clofibrate / pharmacology* Diet Intestinal Absorption / drug effects* Intestine, Small / metabolism Liver / drug effects, metabolism Male Membrane Proteins / biosynthesis Organic Cation Transport Proteins / biosynthesis PPAR alpha / agonists*, metabolism RNA, Messenger / biosynthesis Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Amino Acid Transport Systems; 0/Antilipemic Agents; 0/Carrier Proteins; 0/Membrane Proteins; 0/Octn1 protein, rat; 0/Organic Cation Transport Proteins; 0/PPAR alpha; 0/RNA, Messenger; 0/Slc22a5 protein, rat; 541-15-1/Carnitine; 637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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